NANOCRYSTAL CALCIUM PHOSPHATIC MATERIALS INTENDED FOR USE IN THE QUALITY OF FILTERS FOR PROTECTION FROM ULTRAVIOLET RADIATION

Svetlana Krivileva, Anastasiya Ginkul

Аннотация


The prospects article considers materials used as inorganic filters in sunscreens and moisturizers existing on the market, lipsticks and powders. The possibility of using synthetic nanocrystalline materials of calcium phosphate composition in cosmetic sun protection products for replacing inorganic filters of titanium dioxide and zinc oxide, traditionally used as filters for ultraviolet radiation, has been determined. It has been shown that ecological pure synthetic nanocrystalline Ca10(PO4)6(OH)2 powders can be obtained using the methods of “green chemistry” from solutions of Ca(OH)2 and H3(PO4)2 grades of “chemically pure” and “analytically pure” The optimal ratios of the initial components and heat treatment regimes are determined, which ensure the production of a powder with a crystal size of 25 – 50 nm at a Ca/P ratio of 1,67. In the heat treatment of powders (after aging) a coarse-grained crystalline structure is formed, the particle size rises to 75 nm. The skin-irritating and skin-resorptive properties of the developed materials were studied on warm-blooded animals guinea pigs of the light mask and white laboratory rats on the change in the intensity of biochemiluminescence of whole animal blood and on the changes in the biochemical parameters of blood serum constants of experimental and control animals. When carrying out a full complex of toxicological and hygienic tests in vivo, it is established that the obtained materials do not possess skin-rending properties and are biocompatible with the tissues of the body.

 

Keywords: synthetic sunscreens, hydroxyapatite, titanium dioxide, inorganic filters, skin irritant, skin-resorbing properties.


Полный текст:

PDF (English)

Литература


References

Freitas, R. A. Jr. (2005). Nanotechnology: nanomedicine and nanosurgery. Int. J. Surg., 3(4), 243 – 246. DOI:10.1016/j.ijsu.2005.10.007.

Malanchuk, V. A., Chekman I. S., Stepanova V. I., & Rybachuk A. V. (2010) Aesthetic Medicine in the Application of High Technologies (Review of Literature and Own Research). Scientific Heraldof National Medical University named after Bogomolets A. A., 6 (80), 3411 – 3415.

Chekman, I. S., Malanchuk, V. A., & Gordeychuk, M. A. (2009). Nanotechnology and nanomaterials: application in dentistry and maxillofacial surgery. Ukraine medical Journal, 6(64), 95 – 97.

Rashke, T. (2003). Review of modern methods of encapsulation. Cosmetic and medicine, 2, 44 – 52.

Chen, X. (2008). Nanosilver: a nanoproduct in medical application. Toxicol. Lett, 176(1), 1 – 12. DOI: 10.1016/ j.toxlet.2007.10.004.

Gupta, U., Agashe, H. B., Asthana, A., & Jain, N. K. (2006). Dendrimers: novel polymeric nanoarchitectures for solubility enhancement. Biomacromoleculs, 7(3), 649 – 658. DOI: 10.1021/bm050802s.

Villalobos-Hernandez, J. R., Müller, C., & Goymann, C. (2006). Sun protection enhancement of titanium dioxide crystals by the use of carnauba wax nanoparticles: The synergistic interaction between organic and inorganic sunscreens at nanoscale. Int. J. Pharm., 322(1), 161 – 170. DOI:10.1016/j.ijpharm.2006.05.037.

Müller, R. N., Petersen, D., Hommoss, R. A., & Pardeike, J. (2007). Nanostructures lipid carriers (NLC) in cosmetic dermal products. Adv. Drug. Deliv. Rev., 59(6), 522 – 530.

DOI:10.1016/j.addr.2007.04.012.

Taylor E., & Webster, Т. (2011). Reducing infections through nanotechnology and nanoparticles. Int. J. of Nanomedicine, 6, 1463 – 1473. DOI: 10.2147/IJN.S22021

Samuylova L. P., & Puchkova T. (2005). Cosmetic chemistry. Moscow, Gelios Publ., 95 – 118.

Loginova L., & Karpenko O. (2000). Hygiene and cosmetics. Astraxan, Modern Book Publ., 43.

Chabovskaya, A. P. (1980). Basics of hygiene. Moscow, Egmont Publ., 96.

Michael, M. (2015). Hydroxyapatite (HAp) for Biomedical Application. Boston: Woodhead, 400 – 404.

DOI: 10.2174/138920110791233343.

Kovalyova, E. S., Filipov, Ya. Yu., Putlyayev, V. I., & Tretykov, Y. D. (2010). Bioresorbable powder materials based on Са10-xNax(PO4)6-х(СO3)х(OH)2 . Scientific notes of Kazan University. Series: Natural Science, 152, 80 – 98.

Barinov, S. M., & Komlev, V. S. (2005). Bioceramics based on calcium phosphates. Moscow, Science Publ., 204.

Alekseeva, O. G. (1974). Allergenicity and danger of toxic substances. Hygiene and sanitation, 10, 82 – 85.

Vladimirov, Yu. A., & Archakov, A. I. (1972). Peroxide oxidation of lipids in biological membranes. Moscow, Science Publ., 320.

Belova, Yu. N. (1972). To the question of registration of superweak bioluminescence. Physical methods and questions of metrology and biomedical measurements. Moscow, Science Publ., 241 – 242.

Література

Freitas, R. A. Jr. (2005) Nanotechnology: nanomedicine and nanosurgery. Int. J. Surg., 3(4), 243 – 246. DOI:10.1016/j.ijsu.2005.10.007

Маланчук, В. А. Естетична медицина в аспекті застосування високих технологій (огляд літератури та власних дослiджень) [Текст] / В. А. Маланчук, І. С. Чекман, В. І. Степанова, А. В. Рибачук // Наук. Вісн. Нац. Мед. ун-та iм. А. А. Богомольця. – 2010. – № 6 (80).– С. 3411 – 3415.

Чекман, И. С. Нанотехнологии и наноматериалы: применение в стоматологии и челюстно-лицевой хирургии [Текст]/ И. С. Чекман, В. А. Маланчук, М. А. Гордейчук // Укр. мед. журнал. – 2009. – № 6 (64). – С. 95 – 97.

Рашке, Т. Обзор современных методов инкапсулирования [Текст] / Т. Рашке // Косметика и медицина. – 2003. – № 2.– С. 44 – 52.

Chen, X. (2008) Nanosilver: a nanoproduct in medical application. Toxicol. Lett, 176(1), 1 – 12.

DOI: 10.1016/j.toxlet.2007.10.004

Gupta, U., Agashe, H. B., Asthana, A., Jain, N. K. (2006) Dendrimers: novel polymeric nanoarchitectures for solubility enhancement. Biomacromoleculs, 7(3), 649 – 658. DOI: 10.1021/ bm050802s.

Villalobos-Hernandez, J. R., Müller, C., Goymann, C. (2006) Sun protection enhancement of titanium dioxide crystals by the use of carnauba wax nanoparticles: The synergistic interaction between organic and inorganic sunscreens at nanoscale. Int. J. Pharm., 322(1), 161 – 170. DOI:10.1016/j.ijpharm.2006.05.037.

Müller, R. N., Petersen, D., Hommoss, R. A., Pardeike, J. (2007) Nanostructures lipid carriers (NLC) in cosmetic dermal products. Adv. Drug. Deliv. Rev., 59(6), 522 – 530.

DOI:10.1016/j.addr.2007.04.012.

Taylor E., & Webster, Т. (2011). Reducing infections through nanotechnology and nanoparticles. Int. J. of Nanomedicine, 6, 1463 – 1473. DOI: 10.2147/IJN.S22021.

Самуйлова, Л. П. Косметическая химия [Текст] / Л. П. Самуйлова, Т. Пучкова. – М.: Гелиос. – 2005. – С. 95 – 118.

Логинова, Л., Гигиена и косметика [Текст] / Л. Логинова, О. Карпенко. – Астрахань: Современная книга. – 2000. – 43 с.

Чабовская, А.П. Основы гигиены [Текст] / А. П. Чабовская. – М.: Эгмонт. – 1980. – C. 96.

Michael, M. (2015) Hydroxyapatite (HAp) for Biomedical Application. Boston: Woodhead, 400 – 404.

DOI: 10.2174/138920110791233343.

Ковалева, Е. С. Биорезорбируемые порошковые материалы на основе Са10-xNax(PO4)6-х(СO3)х(OH)2 [Текст] / Е. С. Ковалева, Я. Ю. Филиппов, В. И. Путляев, Ю. Д. Третьяков // Ученые записки Казанского университета. Серия: Естественные науки. – 2010. – Том. 152. – C. 80 – 98.

Баринов, С. М. Биокерамика на основе фосфатов кальция [Текст] / С. М. Баринов, В. С. Комлев. – М.: Наука, 2005.– 204 c.

Алексеева, О. Г. Аллергенность и опасность токсических веществ [Текст] / О. Г. Алексеева // Гиг. и сан. – 1974.– № 10. – С. 82 – 85.

Владимиров, Ю. А. Перекисное окисление липидов в биологических мембранах [Текст] / Ю. А. Владимиров, А. И. Арчаков. // М.: Наука. – 1972. – 320 c.

Белова, Ю. Н. К вопросу о регистрации сверхслабой биолюминисценции [Текст] / Ю. Н. Белова // Физические методы и вопросы метрологии и биомедицинских измерений.– М.: Наука, 1972. – C. 241 – 242.


Ссылки

  • На текущий момент ссылки отсутствуют.


ISSN (print) 2522-1809; ISSN (online) 2522-1817